IPCC - The Possibility Of Large-scale (Continental Or Global), Irreversible Changes In Earth Systems Resulting In Widespread And Sustained Impacts Cannot Be Ruled Out.  E-mail
Global Warming & The SIxth Mass Extinction
"The possibility of large-scale (continental or global), irreversible changes in Earth systems resulting in widespread and sustained impacts cannot be ruled out. These possibilities are scenario-dependent, and the range of possibilities is yet to be fully evaluated." -

Examples include a significant slowing of ocean circulation that transports warm water to the North Atlantic; large reductions in the Greenland and West Antarctic ice sheets; much faster warming than expected due to positive feedback effects; and releases of additional greenhouse gases from permafrost regions and coastal sediments.

While these types of changes are currently thought to be low-probability/high-consequence events with widespread and lasting effects, their probability of occurring increases with the magnitude, rate, and duration of global warming." - Intergovernmental Panel on Climate Change